X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation. This process imposes a plethora of questions: How do cells count their X chromosome number and ensure that exactly one stays active? How do they randomly choose one of two identical X chromosomes for inactivation? And how do they stably maintain this state of monoallelic expression? Here, different regulatory concepts and their plausibility are evaluated in the (...) context of theoretical studies that have investigated threshold behavior, ultrasensitivity, and bistability through mathematical modeling. It is discussed how a twofold difference between a single and a double dose of X‐linked genes might be converted to an all‐or‐nothing response and how mutually exclusive expression can be initiated and maintained. Finally, candidate factors that might mediate the proposed regulatory principles are reviewed. (shrink)

The authors discuss concepts of health and disease in Chinese medicine, new interpretative techniques in psychotherapy, concepts of culture and the notion of risk, Brecht's and Wallner's Verfremdung and Wallner's Constructive Realism compared to Glasersfeld's Radical Constructivism. The book shows the rare situation of philosophy becoming concrete.

Many philosophers appeal to intuitions to support some philosophical views. However, there is reason to be concerned about this practice as scientific evidence has documented systematic bias in philosophically relevant intuitions as a function of seemingly irrelevant features (e.g., personality). One popular defense used to insulate philosophers from these concerns holds that philosophical expertise eliminates the influence of these extraneous factors. Here, we test this assumption. We present data suggesting that verifiable philosophical expertise in the free will debate-as measured by (...) a reliable and validated test of expert knowledge-does not eliminate the influence of one important extraneous feature (i.e., the heritable personality trait extraversion) on judgments concerning freedom and moral responsibility. These results suggest that, in at least some important cases, the expertise defense fails. Implications for the practice of philosophy, experimental philosophy, and applied ethics are discussed. (shrink)

Farming of fish and other aquatic species has increased in recent decades and never before have there been more controversial debates on animal welfare in fish husbandry. The practices used and associated welfare issues are becoming increasingly focused on by scientists, consumers and policy makers. International and national organisations have issued recommendations and guidelines concerning fish welfare but there is still a lot of information lacking. Due to § 2 of the German animal protection law, animals must be adequately nourished, (...) cared for and behaved in a proper manner, and pain or avoidable suffering or damage must be avoided. Keeping fish in accordance with the animal protection laws should be part of a good professional aquaculture practice and is indispensable for ethical, legal and economic reasons. As other vertebrates fish have the right of a healthy life with physical and mental integrity, under which they can perform adequately.The paper provides and discusses legal aspects of animal protection applied to fish taking the German welfare act and EU regulations as example. First possible indicators for the assessment of well-being will be mentioned. The assessment of fish welfare indicators should be carried out within the frame of daily and regular working routines, e. g. feeding, harvesting, grading or slaughtering. Further customer’s perception and human interpretation of welfare in fish are discussed and set into the context of human sentiments, projected on fish and the debate on consciousness in fish. (shrink)

Statements about the behavior of biochemical entities (e.g., about the interaction between two proteins) abound in the literature on molecular biology and are increasingly becoming the targets of information extraction and text mining techniques. We show that an accurate analysis of the semantics of such statements reveals a number of ambiguities that have to be taken into account in the practice of biomedical ontology engineering: Such statements can not only be understood as event reporting statements, but also as ascriptions of (...) dispositions or tendencies that may or may not refer to collectives of interacting molecules or even to collectives of interaction events. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Statements about the behavior of biological entities, e.g. about the interaction between two proteins, abound in the literature on molecular biology and are increasingly becoming the targets of information extraction and text mining techniques. We show that an accurate analysis of the semantics of such statements reveals a number of ambiguities that is necessary to take into account in the practice of biomedical ontology engineering. Several concurring formalizations are proposed. Emphasis is laid on the discussion of biological dispositions.

According to the Thomistic tradition, the Principle of Totality (TPoT) articulates a secondary principle of natural law which guides the exercise of human ownership or dominium over creation. In its general signification, TPoT is a principle of distributive justice determining the right ordering of wholes to their parts. In the medical field it is traditionally understood as entailing an absolute prohibition of bodily mutilation as irrational and immoral, and an imperfect obligation to use the parts of one’s body for the (...) perfection of the bodily whole. TPoT is thus a key element of the system of principles within which an individual exercises her right to life: it helps specify the nature, scope and limits of those actions by which an agent permissibly acts in order to preserve her life. While the Thomistic tradition and the Catholic Church have drawn clear conclusions from the principle regarding, e.g., direct sterilization and non-therapeutic experimentation on human subjects, less attention has been given to the implications of TPoT for non-therapeutic procedures that may positively impact biological functioning or supra-biological goals–that is, for human “enhancement.” We will explore the degree to which TPoT non-univocally guides our use of both artifacts and bodies. We will argue that a careful analysis of these distinct kinds of totalities suggests that the application of TPoT to artifacts and bodies is strongly isomorphic, which is what tempts advocates of the Principle of Autonomy to invalidly infer the absolute dominium of the individual over her body. The inference is invalid because this isomorphism also includes a principle of intrinsic value whose function is to resist the instrumentalization of both artifacts and bodies in some contexts; we are not even related to artifacts as advocates of absolute autonomy believe we are, let alone to our bodies. Rather, the limits of human dominium are determined by the nature and finalities, inherent or acquired, of the objects in question, and it will be argued that articulating these limits raises important, understudied, and fascinating questions about the permissibility of various kinds of human enhancement. (shrink)

Cimpian et al. observed that we accept generic statements of the form ‘Gs are f’ on relatively weak evidence, but that if we are unfamiliar with group G and we learn a generic statement about it, we still treat it inferentially in a much stronger way: all Gs are f. This paper makes use of notions like ‘representativeness’, ‘contingency’ and ‘relative difference’ from psychology to provide a uniform semantics of generics that explains why people accept generics based on weak evidence. (...) The spirit of the approach has much in common with Leslie’s cognition-based ideas about generics, but the semantics will be grounded on a strengthening of Cohen’s relative readings of generic sentences. In contrast to Leslie and Cohen, we propose a uniform semantic analysis of generics. The basic intuition is that a generic of the form ‘Gs are f’ is true because f is typical for G, which means that f is valuably associated with G. We will make use of Kahneman and Tversky’s Heuristics and Biases approach, according to which people tend to confuse questions about probability with questions about representativeness, to explain pragmatically why people treat many generic statements inferentially in a much stronger way. (shrink)

BACKGROUND -/- In biomedical ontologies, mereological relations have always been subject to special interest due to their high relevance in structural descriptions of anatomical entities, cells, and biomolecules. This paper investigates two important subrelations of has_proper_part, viz. the relation has_grain, which relates a collective entity to its multiply occurring uniform parts (e.g., water molecules in a portion of water), and the relation has_component, which relates a compound to its constituents (e.g., molecules to the atoms they consist of). -/- METHOD -/- (...) We distinguish between four kinds of complex entities and characterize them in first order logic. We then discuss whether similar characterizations could be given in description logics, and finally apply the results to mixtures. -/- RESULTS -/- At first sight, collectives and compounds seem to be disjoint categories. Their disjointness, however, relies on agreement about what are uniform entities, and thus on the granularity of description. For instance, the distinction between isomeric subtypes of a molecule can be important in one use case but might be neglected in another one. We demonstrate that, as implemented in the BioTop domain upper level ontology, equivalence or subsumption between different descriptions of same or similar entities cannot be achieved. Using OWL-DL, we propose a new design pattern that avoids primitive subrelations at the expense of more complex descriptions and thus supports the needed inferences. (shrink)

RESUMENNo obstante de sus críticas de la potencialidad filosófica de América, intuiciones y argumentos de Hegel están presentes en los planteamientos de representantes importantes de la Filosofía latinoamericana, aunque siempre de una manera crítica. Conceptos claves del pensamiento de Zea, Roig, Dussel y Ellacuría – como «proyecto asuntivo», «sujeto empírico», «analéctica» y «respectividad» - indican al mismo tiempo el foco de sus discusiones con Hegel. Tal análisis permite la conclusión sorprendente de que Hegel ofrece elementos esenciales para el esbozo de (...) una filosofía intercultural.PALABRAS CLAVESHEGEL EN LA FILOSOFÍA LATINOAMERICANA, PROYECTO ASUNTIVO, ANALÉCTICA, RESPECTIVIDAD, FILOSOFÍA INTERCULTURALABSTRACTDespite Hegel’s critique of American’s philosophical potentiality, Hegel’s intuitionsand arguments are present in approaches of important representatives of Latin American philosophy, although always in a critical manner. Zea’s, Roig’s, Dussel’s and Ellacuría’s key concepts - such as the «assumptive project», «empirical subject», «analectic» and «respectivity» –indicate at the same time the focus of their discussion with Hegel. The analysis of the discussion with Hegel permits the surprising conclusion that Hegel offers essential elements for an outline of an intercultural philosophy.KEY WORDSHEGEL IN LATIN AMERICAN PHILOSOPHY, ASSUMPTIVE PROJECT, ANALECTIC, RESPECTIVITY, INTERCULTURAL PHILOSOPHY. (shrink)

G protein‐coupled receptors (GPCRs) constitute the largest family of transmembrane proteins and play a crucial role in regulating diverse cellular functions. They transmit their signaling via binding to intracellular signal transducers and effectors, such as G proteins, GPCR kinases, and β‐arrestins. To influence specific GPCR signaling behaviors, β‐arrestins recruit effectors to form larger signaling complexes. Intriguingly, they facilitate divergent functions for the binding to different receptors. Recent studies relying on advanced structural approaches, novel biosensors and interactome analyses bring us closer (...) to understanding how this specificity is achieved. In this article, we share our hypothesis of how active GPCRs induce specific conformational rearrangements within β‐arrestins to reveal distinct binding interfaces, enabling the recruitment of a subset of effectors to foster specialized signaling complexes. Furthermore, we discuss methods of how to comprehensively assess β‐arrestin conformational states and present the current state of research regarding the functionality of these multifaceted scaffolding proteins. (shrink)

Background: SNOMED CT is a large terminology system designed to represent all aspects of healthcare. Its current form and content result from decades of bottom-up evolution. Due to SNOMED CT’s formal descriptions, it can be considered an ontology. The Basic Formal Ontology (BFO) is a foundational ontology that proposes a small set of disjoint, hierarchically ordered classes, supported by relations and axioms. In contrast, as a typical top-down endeavor, BFO was designed as a foundational framework for domain ontologies in the (...) natural sciences and related disciplines. Whereas it is mostly assumed that domain ontologies should be created as extensions of foundational ontologies, a post-hoc harmonization of consolidated domain ontologies in use, such as SNOMED CT, is known to be challenging. Methods: We explored the feasibility of harmonizing SNOMED CT with BFO, with a focus on the SNOMED CT Clinical Finding hierarchy. With more than 100,000 classes, it accounts for about one third of SNOMED CT’s content. In particular, we represented typical SNOMED CT finding/disorder concepts using description logics under BFO. Three representational patterns were created and the logical entailments analyzed. Results: Under a first scrutiny, the clinical intuition that diseases, disorders, signs and symptoms form a homogeneous ontological upper-level class appeared incompatible with BFO’s upper-level distinction into continuants and occurrents. The Clinical finding class seemed to be an umbrella for all kinds of entities of clinical interest, such as material entities, processes, states, dispositions, and qualities. This suggests the conclusion that Clinical finding would not be a suitable upper-level class from an BFO perspective. On closer inspection of the taxonomic links within this hierarchy and the implicit meaning derived thereof, it became clear that Clinical finding classes do not characterize the entity (e.g. a fracture, allergy, tumor, pain, hemorrhage, seizure, fever) in a literal sense but rather the condition of a patient having that fracture, allergy, pain etc. This gives sense to the current characteristic of the Clinical Finding hierarchy, in which complex classes are modeled as subclasses of their constituents. Most of these taxonomic links are inferred, as the consequence of the ‘role group’ design pattern, which is ubiquitous in SNOMED CT and has often been subject of controversy regarding its semantics. Conclusion: Our analyses resulted in the proposal of (i) equating SNOMED CT’s ‘role group’ property with the reflexive and transitive BFO relation ‘has occurrent part’; and (ii) reinterpreting Clinical Findings as Clinical Occurrents, i.e. temporally extended entities in an organism, having one or more occurrents as temporal parts that occur in continuants. This re-interpretation was corroborated by a manual analysis of classes under Clinical Finding, as well as the identification of similar modeling patterns in other ontologies. As a result, SNOMED CT does not require any content redesign to establish compatibility with BFO, apart from this re-interpretation, and a suggested re-labeling. Regarding the feasibility of harmonizing terminologies with principled foundational ontologies post-hoc, our results provide support to the assumption that this does not necessarily require major redesign efforts, but rather a careful analysis of the implicit assumptions of terminology curators and users. (shrink)

Anscombe's Intention: A Guide. By Schwenkler John.

To prevent ordinary people from being harmed by natural language processing (NLP) technology, finding ways to measure the extent to which a language model is biased (e.g., regarding gender) has become an active area of research. One popular class of NLP bias measures are bias benchmark datasets—collections of test items that are meant to assess a language model’s preference for stereotypical versus non-stereotypical language. In this paper, we argue that such bias benchmarks should be assessed with models from the psychometric (...) framework of item response theory (IRT). Specifically, we tie an introduction to basic IRT concepts and models with a discussion of how they could be relevant to the evaluation, interpretation and improvement of bias benchmark datasets. Regarding evaluation, IRT provides us with methodological tools for assessing the quality of both individual test items (e.g., the extent to which an item can differentiate highly biased from less biased language models) as well as benchmarks as a whole (e.g., the extent to which the benchmark allows us to assess not only severe but also subtle levels of model bias). Through such diagnostic tools, the quality of benchmark datasets could be improved, for example by deleting or reworking poorly performing items. Finally, in regards to interpretation, we argue that IRT models’ estimates for language model bias are conceptually superior to traditional accuracy-based evaluation metrics, as the former take into account more information than just whether or not a language model provided a biased response. (shrink)

Problem: Visions of technology, future scenarios, guiding visions represent imaginations of future states of affairs that play a functional role in processes of technological research, development and innovation—e.g. as a means to create attention, communication, coordination, or for the strategic exertion of influence. Since a couple of years there is a growing attention for such imaginations of futures in politics, the economy, research and the civil society. This trend concerns technology assessment as an observer of these processes and a consultant (...) on the implications of technology and innovation. TA faces increasing demands to assess imaginations of futures that circulate in the present and to participate in shaping these through scenarios or foresights. More than ever, this raises the question, which propositions can be made based on these imaginations by TA and how this can be used in advisory practices. Imaginations of futures are relevant for TA not as predictions but in their significance and effectiveness in the present, which need to be understood and assessed.Contents: This discussion paper outlines how present significance and effects of imagined futures in technological research and innovation processes can be conceived and analyzed. In this paper, all forms of imaginations of technology futures will be called “socio-technical futures” because within them technological developments and social changes are interwoven and inseparably interrelated. In this paper, we discuss why TA should analyze socio-technical futures, how such analyses can grasp the societal conditions that are expressed in the imagined futures and how these become effective in processes of technology development, communication, decision making etc. We raise the question which self-reflexive positioning or possible realignment of TA is needed as a response to its increased concern with assessing and even co-producing socio-technical futures. The latter is often demanded regarding the growing attention by politics and publics to imaginations of futures with wide temporal and spatial reach.Addressee of this paper is the TA community in a broader sense. The aim is to sensitize colleagues for the topic and its challenges, to consolidate discussions and to provide theoretical and methodical suggestions for research in TA and related advisory practices with respect to socio-technical futures. This paper has been originally initiated during the workshop “The present of technological futures-theoretical and methodical challenges for Technology Assessment”, in which all of the paper’s authors participated. The contents of this discussion paper are preliminary results that shall initiate and guide further discussions. (shrink)

In this chapter, Robb Dunphy is concerned with the nature of G.E. Schulze's scepticism as he presents it in his 1792 work Aenesidemus, and with its relation to the metaphysical projects of Kant, Reinhold, and later German Idealists. After introducing Schulze's text, Dunphy turns to a recent interpretation offered by Jessica Berry, who claims that the extent to which Schulze endorsed a genuinely Pyrrhonian Scepticism has gone unacknowledged, both by his idealist contemporaries and by the majority of the secondary literature (...) on the period. Berry suggests that this unacknowledged Pyrrhonism in Aenesidemus provides the resources for a more radical criticism of the German Idealists' scientific, systematic metaphysical ambitions, to which they remain fundamentally vulnerable. Despite agreeing that an exploration of Schulze's debt to Pyrrhonism represents a valuable addition to our understanding of his scepticism, in the latter parts of the chapter Dunphy suggests that the Berry's attribution of a Pyrrhonian Scepticism to Schulze should to some extent be rejected, and that such a scepticism is perhaps not quite as problematic for the projects of Kant and the German Idealists as she suggests. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:J. G. Fichte's Foundations of the Entire Wissenschaftslehre and Related Writings, 1794–95 by J. G. FichteIsabelle Thomas-FogielJ. G. Fichte. J. G. Fichte's Foundations of the Entire Wissenschaftslehre and Related Writings, 1794–95. Edited and translated by Daniel Breazeale. Oxford: Oxford University Press, 2021. Pp. 608. Hardback, $145.00.This edition of texts written or taught by Fichte between February 1794 and the winter of 1794–95 is a major editorial event and (...) is destined to become the indispensable working tool for all English-speaking students and researchers interested in Fichte. Daniel Breazeale, one of the greatest Fichte specialists, offers here four essential texts. First, the heart of this edition and of Fichte's philosophy, is Foundation of the Entire Wissenschaftslehre (literally "Doctrine of Science") of 1794–95. This central text has already been translated into English by Peter Heath and John Lachs under the title Science of Knowledge (New York: Appleton Century Crofts, 1970), but as Breazeale explains in his preface, he corrected the errors in translation and above all wished to propose a version that was "as broadly accessible as possible" (xi). This is a great challenge, given that this version of the Wissenschaftslehre (henceforth WL) is considered one of the most abstract and difficult texts in philosophy. Let us recall that the term 'WL' qualifies Fichte's entire undertaking and not just one of his works; Fichte thus professed more than fifteen versions of the WL.With this fundamental text, we are also offered a revised translation of two essays (which Breazeale had already edited in 1988): Concerning the Concept of the WL, or of So-Called 'Philosophy' (April–May 1794) and Outline of What is Distinctive of the WL with Regard to the Theoretical Power (winter 1794–95). Finally, Breazeale translates for the first time into English The Zurich WL, the lectures Fichte gave before a small committee from February 24 to April 26 of 1794. With this book, English-speaking readers thus have at their disposal, [End Page 334] in a single volume, some of the most fundamental writings of Fichte's first philosophy. The precision and clarity of this translation will, if not "force the reader to understand," to use a well-known title of Fichte, at least help the reader to appreciate one of the culminating points of idealism.But there is much more to this edition than a precise, fluent, and illuminating translation. It includes, first, an introduction of about one hundred pages that details Fichte's bibliographical, historical, and philosophical journey; then, endnotes that clarify certain moments of the text by placing them in their context, identifying the opponents targeted by Fichte, and restoring the debates of the time; lastly, a German-English and English-German glossary and an index. It is a considerable work, the fruit of a lifetime of research, which will introduce many beginners to Fichte's philosophy and at the same time renew many specialist debates. And it is undoubtedly a strength of this edition that it can be read at several levels, by the beginner as well as by the most experienced researcher.As this review cannot deal with all the rich analyses in Breazeale's introduction, I will give just a few examples. Breazeale first endeavors to reconstruct the genesis of Fichte's questioning. Indeed, the work of the historian of philosophy—as R. G. Collingwood conceived of it—consists first of all in restoring as closely as possible the question to which the text is intended to provide an answer. So, what question or problem was the source of his philosophy that he felt the need to rename WL? Fichte's initial problem was that of the foundation of transcendental idealism. The criticisms of skeptics like Gottlob E. Schulze (also known as "Aenesidemus") or Salomon Maimon had revealed the inadequacy of the foundations laid down by both Kant and Reinhold. As Fichte says and Breazeale reminds us, "The system has to be rebuilt" (4). This rebuilding is the common object of these four translated texts. In this respect, the Zurich lectures (of which only a small part remains) are the witness of this foundation work. Reading these... (shrink)

Part One of Fichte’s 1794/95 Foundation of the Entire Wissenschaftslehre sets forth three basic principles (Grundsätze) as the founding claims of a ‘theory of science’ that should continue and consolidate Kant’s work by vindicating and integrating the theoretical and practical essentials of the Critical philosophy. These principles (my translations) are: (1) “The I originally absolutely posits its own being.” (2) “A not-I is absolutely opposed to the I”; ergo, “opposition in general is absolutely posited by the I.” (3) “In the (...) I, the I opposes a divisible not-I to the divisible I.” This essay explores the ways in which these principles both (i) structure Fichte’s own post-Kantian position and (ii) seek to neutralize some important criticisms of the broader Kantian project. In particular, I argue that Fichte’s principles draw upon a distinctively Kantian conception of pure-rational activity, as the autonomous origination and instatement of pure order-inducing forms: non-sensory notions that inform all truth-apt cognition, and affect-independent norms that orient all autonomous volition. Accordingly, the principle, “the I originally absolutely posits its own being” describes the transcendentally most basic instance of such activity: that pure-rational act upon which all other such acts – ergo, all articulate cognition and all principled agency – ultimately depend. For Fichte, this is an act in which the I conceptually positions rational activity as such, in its strict purity and unmitigated autonomy, as both essentially constitutive of and unconditionally normative for its own existence. Thus the first principle of Fichte’s system figures the most basic pure-rational act as both theoretically determinative and practically legislative – with the consequence that even our most basic cognitive accomplishments depend upon a broadly ethical vocation intrinsic to rationality itself. After making the case for that interpretation, I also, more briefly, discuss the ways in which Fichte’s principles underwrite his responses to some trenchant criticisms of the broader Kantian project: the ‘Humean skepticism’ of G. E. Schulze and the ‘Kantian skepticism’ of Salomon Maimon. (shrink)

This is a draft translation of the fourth letter of G.E. Schulze's Aenesidemus. Comments and corrections welcome.

In Aenesidemus, G.E. Schulze adopts the skeptical voice of Aenesidemus and engages in critical dialogue with Hermias, a Kantian, in the hopes of laying bare what he views as the fundamental issues of K.L. Reinhold’s version of critical philosophy. While some attacks reveal a deep misunderstanding of Reinhold’s Elementarphilosophie on Schulze’s part, others hit their mark. In the Aenesidemus Review (1794), J.G. Fichte at times agrees with criticisms raised by Aenesidemus and at times defends Reinhold against them. On Fichte’s view, (...) Schulze succeeds in proving that the first principle of Reinhold’s Elementarphilosophie, the principle of consciousness (Satz des Bewußtseins), is neither self-evident nor self-determining. Therefore, it cannot be the first principle of philosophy. However, Schulze fails to dissuade Fichte from viewing Reinhold’s principle of consciousness as the pithiest expression of human consciousness of the time. For these reasons, Fichte holds that Reinhold’s principle of consciousness must be deduced from an even higher principle. The goal of this paper is to assess whether Fichte puts forth his own candidate for the first principle of philosophy in his Aenesidemus Review. (shrink)

Arthur Schopenhauer (born 1788 in Danzig, died 1860 in Frankfurt am Main), was the son of Heinrich Floris Schopenhauer, a wealthy merchant, and Johanna Trosiener, who was later to become a well‐known member of Goethe's circle in Weimar and, subsequently, a popular novelist whose collected works, published in 1831, filled twenty‐four volumes. The death of his father (a probable suicide) in 1805 led to the future philosopher's ultimate abandonment of the plan that he should enter business. After further study, he (...) attended the University of Göttingen in 1809 where he studied with G. E. Schulze, whose Aenisidisumus (1796), with its critique of Kant's conception of the thing‐in‐itself, had played a crucial role in the early development of Fichte's Wissenschaftslehre. It was through Schulze that he became acquainted, not only with Kant, but with Plato and Schelling (see Hübscher 1989, pp. 159ff). The connection between Plato and Kant, a crucial thesis of his philosophy as a whole, is the subject of some of his earliest and most penetrating notebook entries (Schopenhauer 1988, vol. I, nos 17, 228, 442). Schopenhauer left Göttingen for Berlin to attend Fichte's lectures. Despite apparently serious attempts, testified by his voluminous notebooks (preserved in Schopenhauer 1988, vol. II), Schopenhauer found himself deeply out of sympathy with the Fichtean philosophy of reflection, and his distaste for German idealism, which only increased with the years, dates from this encounter. On the heels of Napoleon's invasion of Berlin, Schopenhauer retired to a small town outside of Weimar, where (June‐November 1813) he wrote his dissertation On the Fourfold Root of the Principle of Sufficient Reason, whose simplification and transformation of the Kantian doctrine of the concepts of the understanding into a third “form of intuition” next to space and time forms the basis of his distinctive epistemology and its difference from Kant's. (This difference is most clearly expressed in §21; see also the “Critique of Kantian Philosophy”, the Appendix to The World as Will and Representation, vol. I, pp. 437–451). The “ideality of sensation” is the theme of On Vision and Colors, written in 1815 under the influence of his encounter with Goethe's Farbenlehre (a sympathy not reciprocated by Goethe for the younger man's contribution). At this time, Schopenhauer moved to Dresden, where for four years he worked out The World as Will and Representation in intellectual isolation. In addition to the dual influence of Plato and Kant, Schopenhauer had also been introduced to doctrines of Eastern religion by F. Meyer in Weimar (1813), and is often said to be the first Western philosopher seriously to incorporate Eastern thought into his system (see Schopenhauer 1988, vol. I, no. 564). The “work” is announced in a note that is even earlier, from 1813, which begins. (shrink)

The appropriateness, or acceptability, of a conditional does not just ‘go with’ the corresponding conditional probability. A condition of dependence is required as well. In this paper a particular notion of dependence is proposed. It is shown that under both a forward causal and a backward evidential reading of the conditional, this appropriateness condition reduces to conditional probability under some natural circumstances. Because this is in particular the case for the so-called diagnostic reading of the conditional, this analysis might help (...) to explain some of Douven and Verbrugge’s empirical observations. (shrink)

Advances in genetic research have created the need to inform consumers. Yet, the communication of hereditary risk and of the options for how to deal with it is a difficult task. Due to the abstract nature of genetics, people tend to overestimate or underestimate their risk. This paper addresses the issue of how to communicate risk information on hereditary breast and ovarian cancer through an online application. The core of the paper illustrates the design of OPERA, a risk assessment instrument (...) that applies the UK National Institute of Health and Clinical Excellence's guidelines on the basis of (i) the number of relatives on the same side of the family with the same cancer or cancers that are known to run together; (ii) the ages of these relatives at diagnosis and (iii) the closeness of the family relationship with the person who is doing the assessment. By relying on the argumentation theory, we explain how the communication strategy that OPERA implements is essentially based on Perelman and Olbrechts-Tyteca's deductive argumentation by association. By using as premises “facts” (propositions about reality that can be assumed without further justification) and “truths” (propositions that make connections about facts), OPERA delivers its claims with an ex auctoritate causal link aimed at transferring the audience's acceptance of the cause to the effect. Overall, the design of OPERA rests on its capacity to induce users' active processing of risk information through an appeal to their reasoning faculty. In the conclusion, we present some results from a pilot evaluation of users' acceptance of OPERA. (shrink)

In terms of Groenendijk and Stokhofs (1984) formalization of exhaustive interpretation, many conversational implicatures can be accounted for. In this paper we justify and generalize this approach. Our justification proceeds by relating their account via Halpern and Moses (1984) non-monotonic theory of only knowing to the Gricean maxims of Quality and the first sub-maxim of Quantity. The approach of Groenendijk and Stokhof (1984) is generalized such that it can also account for implicatures that are triggered in subclauses not entailed by (...) the whole complex sentence. (shrink)

Schieche, W. Daten zum Leben von Friedrich Wilhelm Joseph Schelling.--Schulz, W. Freiheit und Geschichte in Schellings Philosophie.--Jacobs, W. G. Schellings Anfänge zwischen Orthodoxie und Revolution.--Benz, E. Schellings schwäbische Geistesahnen.

The study of the “first wave” of reactions to the Critique of Pure Reason in Germany from the second half of the 1780s until the beginning of the nineteenth century reveals the paradoxical status of the Kantian transcendental subject. While the existence of the transcendental subject, whatever the term means, is not open to question since it arises from the very essence of critical philosophy, the fundamental status of the subject is sometimes questioned in this period. Although the meaning of (...) the concept of transcendental subject seems obvious today it lends itself to various interpretations in the late eighteenth century. To achieve my goal I have undertaken a textological analysis of the works of the earliest opponents and followers of the Kantian critique and a reconstruction of the conceptual field in the midst of which the transcendental subject has been planted. Among others I draw on the works of J. S. Beck, J. A. Eberhard, J. G. Hamann, F. H. Jacobi, S. Maimon, K. L. Reinhold, G. E. Schulze and A. Weishaupt. The authors of the period are grouped depending on the common themes and questions that prompted them to turn to the concept of the transcendental subject, even though the results of their reflections did not always coincide. These authors think of the transcendental subject in its relationship to the transcendental object, or as “something = х”, and in terms of the relationship of representation to the object. It is characterised sometimes as something absolutely hollow, and sometimes as the fullness of true reality. The status ascribed to the transcendental subject is sometimes that of a thing-in-itself and sometimes that of a “mere” idea. Finally, Kant’s transcendental subject was sometimes seen as something to be overcome and sometimes as an infinite challenge to understanding. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Kant und das Problem des metaphysischen Idealismusby Dietmar H. HeidemannKonstantin PollokDietmar H. Heidemann. Kant und das Problem des metaphysischen Idealismus. Kantstudien Ergänzungshefte 131, Berlin, New York: Walter de Gruyter, 1998. Pp. 268. Cloth, DM 158.00.Immanuel Kant’s critical philosophy was controversial from the very beginning. His refutations of idealism played an important part in these debates. Dietmar H. Heidemann’s book on the problem of idealism is an attempt to (...) evaluate Kant’s arguments against metaphysical idealism. Yet Heidemann never takes a position on whether Kant eventually succeeded or failed in refuting idealism. On the one hand, he thinks it is possible “to consider the proof of the existence of the external world as ultimately unsatisfactory” (238). On the other hand he ambiguously talks of Kant’s “solution of the problem of metaphysical idealism, which is, though not satisfactory in all parts, still quite convincing and even plausible” (238). This indecisiveness constitutes a fundamental shortcoming in an otherwise interesting discussion of a central Kantian problem. The book is distinguished by its close reading of the relevant Kantian texts between 1781 and 1800 and its scrupulous rendering of the respective steps of Kant’s argumentation.Heidemann’s well written investigation consists of an introduction, dealing with the pre-Kantian discussion of that problem, followed by three chapters that present Kant’s criticism of “metaphysical idealism” (3). The author lumps together the theories of Descartes’s ‘skeptical’ or ‘problematic’ idealism and Berkeley’s ‘dogmatic’ idealism with this non-Kantian term. The three chapters correspond to different chronological stages in Kant’s attempts at refuting idealism. First, Heidemann analyzes the structure of the Fourth Paralogism of the Critique of Pure Reason, which was directed against Descartes. This argument was intended to prove that our knowledge of the external world is [End Page 175]immediate. Kant appeals to a radical difference between transcendental and empirical idealism on the one hand and transcendental and empirical realism on the other, and he claims that doubts about the external world that are based on discursive argumentscan be dismissed as illegitimate in principle. Heidemann criticizes Kant’s argumentation. In particular, he thinks that the immediacy of our perceptions alone cannot prove the necessity of outer objects, which could instead be imaginations of immediate objects.In the second chapter, which is unquestionably the center of Heidemann’s study, he analyzes the Refutation of Idealismin the second edition of the Critique. Beginning from its external occasion—the ‘Göttingen review’ by Garve, edited by Feder— Heidemann tries to show that Kant’s refutation of idealism is compelling. He sees Kant’s arguments as implicitly or explicitly informed by the postulate of actuality and the consciousness of one’s existence in time. It is this consciousness that makes necessary the presupposition of something permanent in intuition and thus of substance as matter. In supporting Kant’s sometimes elliptical argumentation with other passages from the Critique, Heidemann tries to improve on Kant’s text. Yet, he is doubtful as to whether the argument succeeds. He thinks that the refutation of idealism would remain insufficient, unless the “theory of self-affection ( Selbstaffektion)” (127), added in 1787, is taken into consideration. In other words, the refutation depends on Kant’s revision of the relationship between the inner and the outer sense in the B-Deduction.The third chapter examines Kant’s occupation with the refutation of idealism after 1787. Heidemann finds that Kant continues to be preoccupied with this subject because of Eberhard’s articles in his Philosophisches Magazin, G. E. Schulze’s Aenesidemus, and D. Tiedemann’s Theaetet. Using Kant’s Reflexionsbetween 1788 and 1800, Heidemann argues that Kant’s new approach is characterised mainly by a decreasing importance of the permanent in the determination of time and a new emphasis of the coexistence argument. But this is questionable for Kant relies on the synthetic connection between the categories of coexistence and substance in the Critique. Heidemann pays a great deal of attention to Kant’s Reflexion “On inner sense” because of its explicit consideration of the relationship between the inner and the outer sense. Heidemann views this passage as “Kant’s... (shrink)

Many philosophers have claimed that normative error theorists are committed to the claim ‘Error theory is true, but I have no reason to believe it’, which to some appears paradoxical. Case (2019) has claimed that the normative error theorist cannot avoid this paradox. In this paper, we argue that there is no paradox in the first place, that is once we clear up the ambiguity of the word ‘reason’, both on the error theorist’s side and those that claim that there (...) is a self-defeat problem. Upon clarification, we also raise scepticism to what exactly the nature of self-defeat is meant to be. (shrink)